Delicious Cattle Drive Casserole Layers

As seen in Satisfying Entrées for Every Table.

Get ready for something that screams comfort. You brown ground beef with onions and red peppers, sprinkle in some taco spice so every bite pops. Start with biscuit dough pressed down and baked a bit, which adds that hearty bottom layer. Then smear on a dreamy combo of creamy mayo, sour cream, chilies, and loads of cheddar. You'll swap in salsa and extra cheese next, then let all those layers bubble and get golden. Pop it straight out of the oven and you'll have a hot, cheesy dish that's perfect for sharing. It's festive, filling, and way nostalgic.

Barbara Chef
Created By Sasha
Last updated on Sat, 19 Jul 2025 16:26:50 GMT
Cheesy baked beef slice topped with herbs and sauce. Save Pin
Cheesy baked beef slice topped with herbs and sauce. | foodthingle.com

This cowboy-style layered bake packs bold Tex-Mex vibes into a filling dish. Fluffy biscuit crust meets spiced beef, melts of cheese, and creamy layers that keep folks piling on seconds. It's my top pick anytime I need something easy, crowd-pleasing, or want leftovers that somehow taste even better the next day.

When I first whipped this up, my crew finished every crumb and begged me to make it again. Now, we look forward to it every Saturday night—it’s that much of a hit.

Tasty Ingredients

  • Cheddar cheese blend: brings gooey texture and big sharp bite—freshly shredding gives the best melt
  • Cooking spray: helps your crust come out of the pan clean—don’t skip this
  • Yellow onion: boosts aroma and makes a super savory base—good ones have flaky dry skin
  • Taco seasoning: packs tons of Tex Mex flavor—pick a mix with extra punch
  • Diced green chiles: add gentle spice and smoke—drain 'em so things aren’t soggy
  • Lean ground beef: meaty heart of the dish—look for some with little fat showing for best cook
  • Sour cream: makes things creamy and a bit tangy—full fat has tastiest mouthfeel
  • Mayonnaise: sneaks in richness and keeps the top luscious—get a mayo with a good clean taste
  • Biscuit mix: the magic for a fluffy base—Bisquick's a safe bet for foolproof results
  • Red bell pepper: color plus a hint of sweetness—choose one that feels heavy and solid
  • Garlic powder: takes things up a notch with savory vibes
  • Water: brings biscuit dough together—cold water works best for mixing
  • Salsa: adds a pop of brightness—fresh-tasting jarred types work great

Full Instructions

Bake Time:
Pop this back in your oven, uncovered, for about thirty minutes. You want the top hot and bubbly with browned cheese. Take it out and give it a few moments to cool so slicing is neat and easy.
Add Salsa and Cheese:
Drop spoonfuls of salsa over that creamy layer. Spread what’s left of the cheddar blend on top for max cheesiness and crunch!
Sour Cream Mix:
Stir up sour cream, mayo, chiles, garlic powder, and most of the shredded cheese. Once it’s all creamy, slather this gently over the beef layer.
Assemble Everything:
Spread the hot beef and veggie combo over your pre-baked biscuit crust. Get it even so every forkful is loaded.
Veggies On Deck:
Toss chopped peppers and onion into the meat. Let them soften up for around four minutes so their sweetness comes through. Swirl in taco seasoning, then pull it from the burner.
Biscuit Crust Ready:
Combine your mix with icy water till a dough forms. Spray your pan, press dough across the bottom and up the sides just a smidge. Prebake till it’s just golden so it’ll stand up to the layers without going mushy.
Brown That Beef:
Get your skillet hot and cook your beef, chopping it up small. Let it brown all over. Drain the grease so the dish isn’t heavy.
Preheat:
Start with the oven set to three-fifty so you’re ready when it’s time to put things together.
A gooey slice with cheese and saucy layers. Save Pin
A gooey slice with cheese and saucy layers. | foodthingle.com

The melt of cheese over golden crust is what I crave most—you get a scoop of creamy, beefy goodness that feels a bit nostalgic. It always brings back cozy movie nights with everyone digging in together at the table.

Keep It Fresh

Let leftovers cool, then stick them in a tightly sealed container in your fridge for up to four days. Freezes super well too—just cut into slices, cover with foil or toss into containers. Reheat covered in the oven or zap a bit in the microwave for quick lunches.

Swaps & Extras

Try tossing in Monterey Jack or pepper jack for a little extra zing or kick. Ground turkey works instead of beef. Light sour cream keeps it creamy but not so heavy. Gluten free? Pick up a GF biscuit mix and check your taco seasoning for sneaky wheat.

Serving Ideas

Load up a plate with crisp green salad (lime vinaigrette is awesome) or set it next to rice and beans if you want it extra filling. Top with avocado slices or a big spoonful of sour cream. Tortilla chips make the perfect crunchy scoop for any soft parts left behind.

Layered cheesy casserole slice with fresh herbs. Save Pin
Layered cheesy casserole slice with fresh herbs. | foodthingle.com

Where It Comes From

This comfort classic is inspired by hearty cowboy eats from the campfire, mixed with layered dishes out of the Southwest. Buttery biscuit base shouts out Southern backgrounds while those peppers and spiced meat are straight from Tex Mex kitchens passed down over the years.

Common Recipe Questions

→ Which ground beef should I grab?

Stick with lean stuff, like 85/15 or 80/20. You’ll get loads of flavor without an oily mess in your pan.

→ Can I swap out the cheese?

Totally! Cheddar always works, but you can toss in Monterey Jack, pepper jack, or even a Mexican blend for extra kick.

→ How about prepping this the night before?

Go for it. Layer everything, cover it up, and leave in the fridge overnight. Just bake before you want to eat—super easy.

→ Will it freeze well after it’s cooked?

Yep, just cool it down, wrap up tight, and freeze. When you’re ready, let it thaw in the fridge then warm it back up so it stays tasty.

→ What should I serve on the side?

Try a crisp salad, some simple veggies, or Mexican rice—these cut the rich flavors and fill out the meal.

Beef Casserole Layers

Dig into cheesy, creamy ground beef stacked with salsa over a tasty biscuit base—super bold and satisfying.

Preparation Time
20 Minutes
Cooking Time
40 Minutes
Overall Time
60 Minutes
Created By: Sasha

Recipe Type: Main Dishes

Skill Level: Moderate

Regional Style: Tex-Mex

Output: 8 Number of Servings (One 9 x 13 inch casserole)

Special Diets: ~

What You'll Need

→ For the Casserole Base

01 Cooking spray
02 1 cup water
03 2 1/2 cups biscuit mix, like Bisquick

→ For the Filling and Topping

04 1/2 cup mild salsa
05 1.5 pounds lean ground beef
06 1 red bell pepper, chopped and seeded
07 1 yellow onion, chopped
08 1 teaspoon garlic powder
09 1 ounce taco seasoning packet
10 1/2 cup sour cream
11 4 ounces diced green chiles, well drained
12 1 1/2 cups shredded cheddar fiesta blend cheese, split
13 1/2 cup mayonnaise

Steps to Follow

Step 01

Let your casserole hang out and cool off for about 10 minutes. It's way easier to cut after that. Dish out and enjoy.

Step 02

Put the dish back into the oven with nothing covering it. Let it bake for around half an hour until the middle is hot, bubbly, and the top gets golden.

Step 03

Now, grab a spoon and dollop salsa here and there on that creamy layer. Don't smooth it out. Toss the last of the shredded cheese all over the top.

Step 04

Scoop that creamy blended mix on top of your beef layer and spread it out so it covers everything.

Step 05

In a clean mixing bowl, stir together green chiles, sour cream, garlic powder, mayo, and 3/4 cup cheese until the mix is nice and smooth.

Step 06

Spread your beef-and-veggie mix evenly on top of the already baked biscuit layer in your casserole dish.

Step 07

Add chopped onion and bell pepper to your skillet with the browned beef. Stir everything around and let it cook for about four minutes. Dump in the taco seasoning and combine, then take off the heat.

Step 08

Mix biscuit mix with water in a bowl until a dough forms. Spray a 9x13 dish with the cooking spray. Press dough into the dish, making sure it goes all the way to the edges. Pop it in a heated oven for about 5-8 minutes until it’s just set and a little golden. Take it out for now.

Step 09

Place a big skillet on medium-high and toss in the ground beef. Break it up and fry until browned and no pink is left. Drain the fat off.

Step 10

Get your oven warming up to 350°F (177°C) while you get everything else together.

Additional Tips

  1. Craving more heat? Grab medium or hot salsa and maybe throw in some jalapeños with your beef for extra kick.

Essential Tools

  • Large skillet
  • Medium mixing bowls
  • 9 x 13 inch casserole dish

Allergen Information

Always verify ingredient labels for allergens and consult with a healthcare expert if unsure.
  • Has milk and dairy stuff (cheese, sour cream, mayo)
  • Has wheat (biscuit mix)
  • Has eggs (in mayo, maybe in biscuit mix too)

Nutrition Info (Per Serving)

These details are best used as an estimate and shouldn't replace professional health advice.
  • Calories: 483
  • Fat Content: 30 g
  • Carbohydrates: 29 g
  • Protein: 23 g